Total synthesis and absolute configuration determination of (+)-subincanadine F.
نویسندگان
چکیده
The first asymmetric synthesis of indole alkaloid (+)-subincanadine F was successfully accomplished with the uncommon 7-endo-trig stereoselective radical cyclization as the key step and its absolute configuration was thus assigned.
منابع مشابه
An efficient total synthesis and absolute configuration determination of varitriol.
The first total synthesis and the absolute configuration determination of varitriol are described.
متن کاملTotal synthesis of colombiasin A and determination of its absolute configuration.
The total synthesis of the recently reported marine natural product colombiasin A (1) and determination of its absolute configuration are reported. Two Diels-Alder cycloadditions and a palladium-catalyzed rearrangement are employed as key reactions to construct the tetracyclic framework of the target molecule. The enantioselective synthesis of colombiasin A utilizes Mikami's [(S)-BINOL-TiCl2] c...
متن کاملDetermination of absolute configuration of trimeric indole alkaloid, psychotrimine, by first asymmetric total synthesis.
The first asymmetric total synthesis of psychotrimine, a trimeric indole alkaloid, was accomplished via an asymmetric Ireland-Claisen rearrangement to construct a chiral quaternary carbon center, thereby establishing the absolute configuration of psychotrimine.
متن کاملContribution Powerful Novel Chiral Acids for Enantioresolution, Determination of Absolute Configuration, and MS Spectral Determination of Enantiomeric Excess
It is well recognized that molecular chirality is essential to life processes, and that most biologically active compounds controlling physiological functions of living organisms are chiral. Hence, in the structural study of biologically active compounds, including natural products, determination of absolute configuration becomes the first major issue. The second issue is chiral synthesis of na...
متن کاملThree-component procedure for the synthesis of new chiral spirooxindolopyrrolizidines via catalytic highly enantioselective 1,3-dipolar cycloaddition
The catalytic highly regio-, diastereo-, and enantioselective synthesis of a small library of spiropyrrolizidineoxindolesvia a four-component 1,3-dipolar cycloaddition reaction of azomethine ylides, derived from isatin, with electron-deficient dipolarophilewas described. The process occurs at room temperature in aqueous ethanol as a green solvent and in the presence of a bidendatebis(imine)–Cu(...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemical communications
دوره 46 44 شماره
صفحات -
تاریخ انتشار 2010